University of Louisville Magazine

FAL 2016

The University of Louisville Alumni Magazine: for alumni, faculty, staff, students and anyone that is a UofL Cardinal fan.

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F A L L 2 0 1 6 U O F L M A G A Z I N E | 4 5 A C R O S S C A M P U S State fair CPR training wins national award For two consecutive years, Lorrel Brown, MD, has led staff in providing cardiopulmonary resuscitation training to Kentucky State Fair-goers. Her efforts have been recognized with a national award. Brown, assistant professor of medicine, won fi rst place in the "Young Investigator Awards in Cardio- vascular Health Outcomes and Population Genetics" from the American College of Cardiology. Details about the project were published in the Journal of the American College of Cardiology. Brown and her team created a 10-minute training module to teach people the basics of hands-only CPR. "The vast majority of people who suffer cardiac arrest don't experience it in a hospital with trained medical staff," Brown said. "They experience it in their daily lives, and just 30 percent of cardiac arrest victims receive CPR, usually from bystanders. Yet we know that CPR dramatically improves chances for survival." In Kentucky's Jefferson County alone, she said, bystander CPR rates vary dramatically according to zip code. "We know there is the same variation throughout the state, and 77 percent of the Jefferson County residents we trained at the fair were from zip codes with rates under the national average of 31 percent. "These results suggest that by providing training in venues such as the state fair, we can potentially improve the rate of bystander CPR in this country," she said. Lorrel Brown, Jessica Aberli and Travis Carroll volunteer at the 2015 Kentucky State Fair. SCHOOL OF MEDICINE UofL researchers to explore the lifetime effects of cigarette smoke and genetics on infertility In an effort to understand how specifi c genetic factors coupled with lifetime exposure to cigarette smoking and secondhand smoke infl uence a woman's ability to conceive, UofL researchers received an NIH three-year, $440,000 grant. Kira Taylor, PhD, MS, assistant professor, Department of Epidemiology and Population Health, says exposure to tobacco smoke may be more harmful in women who carry the slow metabolizer form of NAT2, a gene that plays an important role in metabolism of toxins present in tobacco smoke and other hazardous substances. "We think that if a woman carries the slow form of the NAT2 gene, cigarette toxins will be metabolized and excreted more slowly, thus exacerbating the effects of smoking hazards — including making infertility problems more pronounced," Taylor said. Taylor and her research team will consider ovarian reserve — a woman's remaining egg count — and in vitro fertilization success rates as they relate to the cumulative impact of smoking, exposure to secondhand smoke and, fi nally, a combination of exposure to tobacco smoke and presence of the NAT2 slow gene. If Taylor and her colleagues fi nd an interaction between NAT2 and smok- ing with regard to ovarian reserve or in vitro fertilization, it could pave the way for more accurate analyses of the effects of smoking. Taylor SCHOOL OF PUBLIC HEALTH AND INFORMATION SCIENCES

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